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KMID : 0644120100230030014
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Journal of Oriental Gynecology
2010 Volume.23 No. 3 p.14 ~ p.25
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Inhibitory effects of Nardostachys Jatamansi on the maturation of dendritic cells
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O Kwang-Woo
Jeong Ji-Hye
Cheong Hyun-Cheol
Cho Han-Baek
Kim Song-Baeg
Choe Chang-Min
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Abstract
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Purpose: The purpose of this study is to investigate inhibitory effect on the maturation of dendritic cells from aqueous extract from Nardostachys Jatamansi(NJ).
Methods: I examined the phenotypic maturation(class II MHC, CD40, CD86), expression of pro-inflammatory cytokine(TNF-, IL-6, IL-12) and endocytosis of FITC-Dextran in the LPS-induced bone marrow-derived dendritic cells(BMDCs) of mice. Furthermore, the Western-blot analysis reveals the mechanism of inhibitory effect.
Results: 1. The NJ extract inhibited the phenotypic maturation of BMDCs in a dose-dependent manner. 2. The NJ extract inhibited the LPS induced cytokine production of BMDCs in a dose-dependent manner. 3. The NJ extract enhanced the endocytosis of Dex-FITC in LPS treated DC. 4. The NJ extract inhibited the activation of JNK and p38 phosphorylation, but not ERK phosphorylation of MAPK family and doesn’t inhibit Ik-Ba degradation in LPS-stimulated BMDCs.
Conclusion: These results suggest that NJ extract is able to attenuate the inflammation and maturation in BMDCs and may inhibit proliferation of T cells. In conclusion, this experiment suggests that NJ extract may be useful in hypersensitivity disease including autoimmune disease.
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KEYWORD
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Nardostachys Jatamansi(NJ), Dendritic cells, Maturation
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